#Kidawara S, #Kimura S, Takano H, Inoue W, Iinuma K, Takahama M, *Takemura N, *Saitoh T (#Co-first authors, *Co-corresponding authors).

Oridonin Suppresses Mast Cell Degranulation and Alleviates Ovalbumin-Induced Allergic Rhinitis.

Biol. Pharm. Bull. 2024, 47, 1920-1926. doi: 10.1248/bpb.b24-00594.

 

Kawai A, Noda M, Hirata H, Munakata L, Matsuda T, Omata D, Takemura N, Onoe S, Hirose M, Kato T, Saitoh T, Hirai T, Suzuki R, Yoshioka Y.

Lipid Nanoparticle with 1,2-Di-O-octadecenyl-3-trimethylammonium-propane as a Component Lipid Confers Potent Responses of Th1 Cells and Antibody against Vaccine Antigen.

ACS Nano. 2024, 18, 16589-16609. doi: 10.1021/acsnano.4c00278.

 

Pan Y, Ikoma K, Matsui R, Nakayama A, *Takemura N, *Saitoh T (*Co-corresponding authors).

Dasatinib suppresses particulate-induced pyroptosis and acute lung inflammation

Front Pharmacol. 2023, 14, 1250383. doi: 10.3389/fphar.2023.1250383.

 

Fukunaka A, Shimura M, Ichinose T, Pereye OB, Nakagawa Y, Tamura Y, Mizutani W, Inoue R, Inoue T, Tanaka Y, Sato T, Saitoh T, Fukada T, Nishida Y, Miyatsuka T, Shirakawa J, Watada H, Matsuyama S, Fujitani Y.

Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model.

Sci Rep. 2023, 13, 3484. doi: 10.1038/s41598-023-30498-y.

​

#Matsui Y, #*Takemura N, Shirasaki Y, Takahama M, Noguchi Y, Ikoma K, Pan Y, Nishida S, Taura M, Nakayama A, Funatsu T, Misawa T, Harada Y, Sunazuka T, *Saitoh T (#Co-first authors, *Co-corresponding authors).

Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction

Int Immunol. 2022, 34, 505-518. doi: 10.1093/intimm/dxac028.

​

Ikoma K, Takahama M, Kimishima A, Pan Y, Taura M, Nakayama A, Arai M, *Takemura N, *Saitoh T (*Co-corresponding authors).

Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung

Int Immunol. 2022, 34, 493-504. doi: 10.1093/intimm/dxac018.

​

Omori S, Tsugita M, Hoshikawa Y, Morita M, Ito F, Yamaguchi SI, Xie Q, Noyori O, Yamaguchi T, Takada A, Saitoh T, Toyokuni S, Akiba H, Nagata S, Kinoshita K, Nakayama M.

Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation.

Cell Rep. 2021, 34, 108734. doi: 10.1016/j.celrep.2021.108734.

 

Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Shimizu S, Higashino T, Koyama T, Hishida A, Kuriki K, Watanabe M, Shimizu T, Ooyama K, Ooyama H, Nagase M, Hidaka Y, Matsui D, Tamura T, Nishiyama T, Shimanoe C, Katsuura-Kamano S, Takashima N, Shirai Y, Kawaguchi M, Takao M, Sugiyama R, Takada Y, Nakamura T, Nakashima H, Tsunoda M, Danjoh I, Hozawa A, Hosomichi K, Toyoda Y, Kubota Y, Takada T, Suzuki H, Stiburkova B, Major TJ, Merriman TR, Kuriyama N, Mikami H, Takezaki T, Matsuo K, Suzuki S, Hosoya T, Kamatani Y, Kubo M, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H; Japan Gout Genomics Consortium (Japan Gout).

Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.

Ann Rheum Dis. 2020, 79, 657-665. doi: 10.1136/annrheumdis-2019-216644.

​

Kawamura Y, Nakaoka H, Nakayama A, Okada Y, Yamamoto K, Higashino T, Sakiyama M, Shimizu T, Ooyama H, Ooyama K, Nagase M, Hidaka Y, Shirahama Y, Hosomichi K, Nishida Y, Shimoshikiryo I, Hishida A, Katsuura-Kamano S, Shimizu S, Kawaguchi M, Uemura H, Ibusuki R, Hara M, Naito M,Takao M, Nakajima M, Iwasawa S, Nakashima H, Ohnaka K, Nakamura T, Stiburkova B, Merriman TR, Nakatochi M, Ichihara S, Yokota M, Takada T, Saitoh T, Kamatani Y, Takahashi A, Arisawa K, Takezaki T, Tanaka K, Wakai K, Kubo M, Hosoya T, Ichida K, Inoue I, Shinomiya N, Matsuo H.

Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.

Ann Rheum Dis. 2019, 78, 1430-1437. doi: 10.1136/annrheumdis-2019-215521.

​

DeVorkin L, Pavey N, Carleton G, Comber A, Ho C, Lim J, McNamara E, Huang H, Kim P, Zacharias LG, Mizushima N, Saitoh T, Akira S, Beckham W, Lorzadeh A, Moksa M, Cao Q, Murthy A, Hirst M, DeBerardinis RJ, Lum JJ.

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.

Cell Rep. 2019, 27, 502-513. doi: 10.1016/j.celrep.2019.03.037.

​

Taufiq F, Maharani N, Li P, Kurata Y, Ikeda N, Kuwabara M, Otani N, Miake J, Hasegawa A, Tsuneto M, Shirayoshi Y, Ninomiya H, Saitoh T, Nakai A, Yamamoto K, Hisatome I.

Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes.

Circ J. 2019, 83, 718-726. doi: 10.1253/circj.CJ-18-1088.

 

Noguchi S, Honda S, Saitoh T, Matsumura H, Nishimura E, Akira S, Shimizu S.

Beclin 1 regulates recycling endosome and is required for skin development in mice.

Commun Biol. 2019,  2, 37. doi: 10.1038/s42003-018-0279-0. 

​

Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.

Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.

Autophagy. 2018,14,764-777. doi: 10.1080/15548627.2017.1314897. 

​

Takahama M, Fukuda M, Ohbayashi N, Kozaki T, Misawa T, Okamoto T, Matsuura Y, Akira S, Saitoh T.
The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses.
Cell Rep. 2017, 20, 2944-2954. doi: 10.1016/j.celrep.2017.08.085. 

Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M.

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.

Nat Immunol. 2017, 18, 899-910. doi: 10.1038/ni.3767.

​

Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T.

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.

Proc Natl Acad Sci U S A. 2017, 114, 2681-2686. doi:10.1073/pnas.1621508114

​

Imagawa Y, Saitoh T, Tsujimoto Y.

Vital staining for cell death identifies Atg9a-dependent necrosis in developmental bone formation in mouse.

Nat Commun. 2016, 7, 13391. doi: 10.1038/ncomms13391.

​

Maruyama K, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, Fujii T, Takemura N, Karuppuchamy T, Kondo T, Kawasaki T, Fukasaka M, Misawa T, Saitoh T, Suzuki Y, Martino MM, Kumagai Y, Akira S.

Bone-protective Functions of Netrin 1 Protein.

J Biol Chem.  2016, 291, 23854-23868. doi: 10.1074/jbc.M116.738518

​

Santeford A, Wiley LA, Park S, Bamba S, Nakamura R, Gdoura A, Ferguson TA, Rao PK, Guan JL, Saitoh T, Akira S, Xavier R, Virgin HW, Apte RS.
Impaired Autophagy in Macrophages Promotes Inflammatory Eye Disease.
Autophagy. 2016, 12, 1876-1885, doi: 10.1080/15548627.2016.1207857

​

Park S, Buck MD, Desai C, Zhang X, Loginicheva E, Martinez J, Freeman ML, Saitoh T, Akira S, Guan JL, He YW, Blackman MA, Handley SA, Levine B, Green DR, Reese TA, Artyomov MN, Virgin HW.

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.

Cell Host Microbe. 2016, 19, 91-101. doi: 10.1016/j.chom.2015.12.010.

​

Lee Y, Sasai M, Ma JS, Sakaguchi N, Ohshima J, Bando H, Saitoh T, Akira S, Yamamoto M.

p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen.

Cell Rep. 2015, 13, 223-233. doi: 10.1016/j.celrep.2015.09.005.

 

Kojima T, Yamada T, Akaishi R, Furuta I, Saitoh T, Nakabayashi K, Nakayama KI, Nakayama K, Akira S, Minakami H.

Role of the Atg9a gene in intrauterine growth and survival of fetal mice.

Reprod. Biol. 2015, 15, 131-138. doi: 10.1016/j.repbio.2015.05.001.

 

#Misawa T, #Saitoh T, Kozaki T, Park S, Takahama M, Akira S.

(#Co-first authors).

Resveratrol inhibits the acetylated a-tubulin-mediated assembly of the NLRP3-inflammasome.

Int Immunol. 2015, 27, 425-434. doi: 10.1093/intimm/dxv018.

† Selected for Outstanding Merit Award 2015 (The Outstanding Merit Award is an annual prize which recognizes the best paper published in International Immunology)

 

Kozaki T, Takahama M, Misawa T, Matsuura Y, Akira S, *Saitoh T.

(*Corresponding author).

Role of zinc-finger antiviral protein in host defense against Sindbis virus.

Int Immunol. 2015, 27, 357-364. doi: 10.1093/intimm/dxv010.

​

Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino M, Akira S.

5-azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.

J Biol Chem. 2015, 290, 9377-9386. doi: 10.1074/jbc.M114.631374.

 

Choi J, Park S, Biering SB, Selleck E, Liu CY, Zhang X, Fujita N, Saitoh T, Akira S, Yoshimori T, Sibley LD, Hwang S, Virgin HW.

The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.

Immunity. 2014, 40, 924-935. doi: 10.1016/j.immuni.2014.05.006.

 

Ohshima J, Lee Y, Sasai M, Saitoh T, Ma JS, Kamiyama N, Matsuura Y, Suh PG, Hayashi M, Ebisu S, Brummelkamp TR, Takeda K, Akira S, Yamamoto M.

Role of the mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.

J Immunol. 2014, 192, 3328-3335. doi: 10.4049/jimmunol.1302822.

 

Ono C, Ninomiya A, Yamamoto S, Abe T, Wen X, Fukuhara T, Sasai M, Yamamoto M, Saitoh T, Satoh T, Kawai T, Ishii KJ, Akira S, Okamoto T, Matsuura Y.

Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.

J Virol. 2014, 88, 2157-2167. doi: 10.1128/JVI.03055-13.

​

Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS.

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production.

EMBO J. 2013, 32, 3130-3144. doi: 10.1038/emboj.2013.233.

 

Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, Umemoto T, Saitoh T, Nakatogawa H, Kobayashi S, Haraguchi T, Guan JL, Saito K, Ishibashi K, Akira S, Fukuda M, Noda T, Yoshimori T.

Recruitment of the autophagic machinery upstream of LC3 is mediated by ubiquitin on host endosomal membranes during infection-induced autophagy.

J Cell Biol. 2013, 203, 115-128. doi: 10.1083/jcb.201304188.

 

Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T, Yamamoto A, Hamasaki M, Noda T, Isaka Y, Yoshimori T.

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury.

EMBO J. 2013, 32, 2336-2347. doi: 10.1038/emboj.2013.171.

 

Lee H, Komano J, Saitoh Y, Yamaoka S, Kozaki T, Misawa T, Takahama M, Satoh T, Takeuchi O, Yamamoto N, Matsuura Y, *Saitoh T, *Akira S.

(*Co-corresponding authors).

Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus.

Proc Natl Acad Sci U S A. 2013, 110, 12379-12384. doi: 10.1073/pnas.1310604110.

 

Misawa T, Takahama M, Kozaki T, Lee H, Zou J, *Saitoh T, *Akira S.

(*Co-corresponding authors).

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome.

Nat Immunol. 2013, 14, 454-460. doi: 10.1038/ni.2550.

 

Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N.

FIP200 regulates targeting of Atg16L1 to the isolation membrane.

EMBO Rep. 2013, 14, 284-291. doi: 10.1038/embor.2013.6.

 

Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T.

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.

Proc Natl Acad Sci U S A. 2013, 110, 2969-2974. doi: 10.1073/pnas.1222694110.

 

Maruyama K, Fukasaka M, Vandenbon A, Saitoh T, Kawasaki T, Kondo T, Yokoyama KK, Kidoya H, Takakura N, Standley D, Takeuchi O, Akira S.

The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.

Immunity. 2012, 37, 1024-1036. doi: 10.1016/j.immuni.2012.08.022.

 

Watanabe TM, Tsukasaki Y, Fujita H, Ichimura T, Saitoh T, Akira S, Yanagida T.

Distinct modulated pupil function system for real-time imaging of living cells.

PLoS One. 2012, 7, e44028. doi: 10.1371/journal.pone.0044028.

 

Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S.

Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.

Cell Host Microbe. 2012, 12, 109-116. doi: 10.1016/j.chom.2012.05.015.

 

Kurokawa K, Ryu KH, Ichikawa R, Masuda A, Kim MS, Lee H, Chae JH, Shimizu T, Saitoh T, Kuwano K, Akira S, Dohmae N, Nakayama H, Lee BL.

Novel bacterial lipoprotein structures conserved in low-GC content Gram-positive bacteria are recognized by Toll-like receptor 2.

J Biol Chem. 2012, 287, 13170-13181. doi: 10.1074/jbc.M111.292235.

 

Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S.

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.

Nat Immunol. 2011, 12, 1167-1175. doi: 10.1038/ni.2137.

 

Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T.

The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.

Mol Biol Cell. 2011, 22, 2290-2300. doi: 10.1091/mbc.E10-11-0893.

 

Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S.

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

Immunity. 2011, 34, 352-363. doi: 10.1016/j.immuni.2011.03.010.

 

Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S.

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA.

Immunity. 2010, 33, 765-776. doi: 10.1016/j.immuni.2010.10.013.

 

Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S.

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.

Nat Immunol. 2010, 11, 936-944. doi: 10.1038/ni.1920.

 

Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T, Noda T, Yoshimori T.

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

J Cell Biol. 2010, 190, 511-521. doi: 10.1083/jcb.200911141.

 

Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T.

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal-Glucan.

J Immunol. 2009, 183, 8061-8067. doi: 10.4049/jimmunol.0902477.

 

Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S.

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.

Proc Natl Acad Sci U S A. 2009, 106, 20842-20846. doi: 10.1073/pnas.0911267106.

 

Fujita N, Saitoh T, Kageyama S, Akira S, Noda T, Yoshimori T.

Differential involvement of ATG16L1 in Crohn's disease and canonical autophagy: analysis of the organization of the ATG16L1 complex in fibroblasts.

J Biol Chem. 2009, 284, 32602-32609. doi: 10.1074/jbc.M109.037671.

 

Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura T, Isobe T, Akira S, Noda T, Yoshimori T.

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

Nat Cell Biol. 2009, 11, 385-396. doi: 10.1038/ncb1846.

 

Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

Nature. 2008, 456, 264-268. doi: 10.1038/nature07383.

 

Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S.

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

Nat Immunol. 2008, 9, 684-691. doi: 10.1038/ni.1606.

 

Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez Bruyn VJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S.

Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.

Blood. 2008, 111, 5118-5129. doi: 10.1182/blood-2007-09-110635.

 

Ochiai T, Saito Y, Saitoh T, Dewan MZ, Shioya A, Kobayashi M, Kawachi H, Muto S, Itai A, Uota S, Eishi Y, Yamamoto N, Tanaka S, Arii S, Yamaoka S.

Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells.

J Med Dent Sci. 2008, 55, 49-59. doi: -.

 

Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S.

Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.

J Exp Med. 2007, 204, 2233-2239. doi: 10.1084/jem.20070183.

 

Qi X, Koya Y, Saitoh T, Saitoh Y, Shimizu S, Ohba K, Yamamoto N, Yamaoka S, Yamamoto N.

Efficient induction of HIV-1 replication in latently infected cells through contact with CD4+ T cells: involvement of NF-kappaB activation.

Virology. 2007, 361, 325-334. doi: 10.1016/j.virol.2006.11.014.

 

Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S.

Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.

J Immunol. 2006, 177, 7520-7524. doi: -.

 

Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S.

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.

Nat Immunol. 2006, 7, 962-970. doi:10.1038/ni1367.

 

Saitoh T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, Akira S, Yamamoto N, Lu KP, Yamaoka S.

Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

Nat Immunol. 2006, 7, 598-605. doi:10.1038/ni1347.

 

Ryo A, Uemura H, Ishiguro H, Saitoh T, Yamaguchi A, Perrem K, Kubota Y, Lu KP, Aoki I.

Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer.

Clin Cancer Res. 2005, 11, 7523-7531. doi: 10.1158/1078-0432.CCR-05-0457.

 

Saitoh T, Yamamoto M, Miyagishi M, Taira K, Nakanishi M, Fujita T, Akira S, Yamamoto N, Yamaoka S.

A20 is a negative regulator of IFN regulatory factor 3 signaling.

J Immunol. 2005, 174, 1507-1512. doi: -.

 

Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S.

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.

Nature. 2004, 430, 218-222. doi:10.1038/nature02738.

 

Saitoh T, Nakayama M, Nakano H, Yagita H, Yamamoto N, Yamaoka S.

TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.

J Biol Chem. 2003, 278, 36005-36012. doi: 10.1074/jbc.M304266200.

 

Saitoh T, Nakano H, Yamamoto N, Yamaoka S.

Lymphotoxin-beta receptor mediates NEMO-independent NF-kappaB activation.

FEBS Lett. 2002, 532, 45-51. doi: 10.1016/S0014-5793(02)03622-0

 

Saitoh T, Tanaka S, Koike T.

Rapid induction and Ca(2+) influx-mediated suppression of vitamin D3 up-regulated protein 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis.

J Neurochem. 2001, 78, 1267-1276. doi: 10.1046/j.1471-4159.2001.00505.x

 

Arakawa Y, Saito T, Saito H, Kakegawa T, Kobayashi H.

Ethylene glycol bis (beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) inhibits the growth of Escherichia coli at alkaline pH.

J Gen Appl Microbiol. 2000, 46, 127-131. doi: -.